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  • Chatterjee S, Vanrobaeys Y,  Gleason AI, Park BJ, Heiney SA, Rhone AE, Nourski KV, Langmack L,  Basu B, Mukherjee U, Kovach CK, Kocsis Z, Kikuchi Y, Ayala YA, Petkov CI, Hefti MM,  Bahl E, Michaelson JJ, Kawasaki H, Oya H, Howard III MA, Nickl-Jockschat T, Lin L-C, Abel T. BiorXiv Link 

The gene expression signature of electrical stimulation in the human brain.

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  • Criscuolo A, Schwartze M, Prado L, Ayala YA, Merchant H, Kotz S. Progress in Neurobiology 2023. Link

Macaque monkeys and humans sample temporal regularities in the acoustic environment. 

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  • Elgueda D, Ayala YA, Delano PH. Front. Neurosci 2022. 

Editorial: Listening in action: Attention, emotions, and cognition in the auditory system. Link

 

  • Gamez J, Yc K, Ayala YA, Dotov D, Prado L, Merchant H. Ann NY Acad Sci 2018. Link

Predictive rhythmic tapping to isochronous and tempo changing metronomes in the nonhuman primate. 

 

  • Ayala YA*, Lehmann A, Merchant H*. Scientific Reports 2017. *Corresponding Author. Link

Monkeys share the neurophysiological basis for encoding sound periodicities captured by the frequency-following response with humans. 

 

  • Ayala YA, Malmierca MS. Brain Structure & Function 2017. Link

The effect of inhibition on stimulus-specific adaptation in the inferior colliculus. 

 

  • Valdes-Baizabal C, Parras GG, Ayala YA, Malmierca MS. Scientific Reports 2017. Link

Endocannabinoid Modulation of Stimulus-Specific Adaptation in Inferior Colliculus Neurons of the Rat. 

 

  • Ayala YA, Pérez-González D, Duque D, Palmer AR, Malmierca MS. JOVE 2016. Link

Extracellular Recording of Neuronal Activity Combined with Microiontophoretic Application of Neuroactive Substances in Awake Mice. 

 

  • Ayala YA, Pérez-González D, Malmierca MS. Biological Psychology 2015. Link

Stimulus-specific adaptation in the inferior colliculus. The role of excitatory, inhibitory and modulatory inputs. 

 

  • Ayala YA, Malmierca MS. Journal of Neuroscience 2015. Link

Cholinergic modulation of stimulus-specific adaptation in the inferior colliculus. 

 

  • Ayala YA, Udeh A, Dutta K, Bishop D, Malmierca M, Oliver D. Scientific Reports 2015. Link

Differences in the strength of cortical and brainstem inputs to SSA and non-SSA neurons in the inferior colliculus. 

 

  • Ayala YA*, Duque D*, Malmierca MS. Cell and Tissue Research 2015. *equal contribution Link

Deviance detection in auditory subcortical structures: what can we learn from their neurochemistry and neuronal connectivity? 

 

  • Ayala YA, Malmierca MS. Frontiers in Neural Circuits 2012. Link

Stimulus-specific adaptation and deviance detection in the inferior colliculus. 

 

  • Ayala YA, Pérez-González D, Duque D, Nelken I, Malmierca MS. Frontiers in Neural Circuits 2012. Link

Frequency discrimination and stimulus deviance in the inferior colliculus and cochlear nucleus. 

 

  • Duque D, Pérez-González D, Ayala YA, Palmer AR, Malmierca MS. J Neuroscience 2012. Link

Topographic distribution, frequency and intensity dependence of stimulus-specific adaptation in the inferior colliculus of the rat. 

 

  • Aleksandrov V, Alexandrova T, Vega R, Castillo G, Reyes M, Aguilar Y, Ortega A, Shulenina N, Soto E. Research in Computing Science 2008. Link

Response of the gravito-inertial mechanoreceptors during a fall: a mathematical model. 

The gene expression signature of electrical stimulation in the human brain

Abstract: Direct electrical stimulation has been used for decades as a gold standard clinical tool to map cognitive function in neurosurgery patients1–8. However, the molecular impact of electrical stimulation in the human brain is unknown. Here, using state-of-the-art transcriptomic and epigenomic sequencing techniques, we define the molecular changes in bulk tissue and at the single-cell level in the human cerebral cortex following direct electrical stimulation of the anterior temporal lobe in patients undergoing neurosurgery. Direct electrical stimulation surprisingly had a robust and consistent impact on the expression of genes related to microglia-specific cytokine activity, an effect that was replicated in mice. Using a newly developed deep learning computational tool, we further demonstrate cell type-specific molecular activation, which underscores the effects of electrical stimulation on gene expression in microglia. Taken together, this work challenges the notion that the immediate impact of electrical stimulation commonly used in the clinic has a primary effect on neuronal gene expression and reveals that microglia robustly respond to electrical stimulation, thus enabling these non-neuronal cells to sculpt and shape the activity of neuronal circuits in the human brain.

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